Ankylosing Spondylitis (AS) is a chronic autoimmune condition that causes inflammation in the spine and sacroiliac joints, leading to pain, stiffness, and reduced flexibility. In severe cases, spinal bones may fuse over time. Although there is no cure, early diagnosis and proper treatment can effectively manage symptoms, improve mobility, and maintain quality of life through physiotherapy, exercise, posture correction, and medication when needed.
AS affects approximately 0.1%–1.4% of the population and is strongly associated with the HLA-B27 gene. It is more common in men than women and typically begins between the ages of 20 and 30, though it can occur later in life.
At SpineMantra, we provide specialized, evidence-based care focused on reducing inflammation, improving mobility, and preventing complications. Our personalized treatment plans combine physiotherapy, posture correction, exercise programs, lifestyle guidance, and medical management to support long-term relief and better function.
An individual’s genetic disposition to Ankylosing Spondylitis is its main causative factor, especially the existence of the HLA-B27 gene that is present in around 70-90% of the patients with AS in India. This gene is capable of causing a malfunctioning immune reaction that might induce the body to begin attacking the joints of the spine and the pelvis that the body sees as a threat. The onset of inflammation is at the sacroiliac joints, and slowly it propagates towards the top of the spine, normally leading to fusing of the vertebrae of the spine.
Interestingly, HLA-B27 carriers do not always develop AS, which, again, implies that environmental factors, i.e., gut microbiome imbalance or specific bacterial infections (e.g., Klebsiella pneumoniae), could serve as triggers in people with a genetic predisposition to this disease. Chronic stress and hormonal imbalance can also enhance the effect of inflammation responses, making the progression of the disease even faster.
Early detection of symptoms is crucial, as the disease often goes unnoticed due to its mild presentation before it progresses.
Anyone can develop ankylosing spondylitis, although certain factors increase the risk:
At SpineMantra, our experts use evidence-based assessment and rehabilitation techniques designed for Ankylosing Spondylitis. Instead of relying on methods suited for mechanical back pain, our approach focuses on targeted physiotherapy, mobility and strengthening exercises, posture correction, and lifestyle guidance. These strategies help reduce stiffness, improve spinal mobility, and support long-term spinal health. The goal of SpineMantra’s treatment is pain relief, improved movement, and slowing disease progression – achieved through a personalised and integrated care plan.
For some, the spine becomes completely stiff, but others have ups and downs with symptoms. Leading a productive life and avoiding severe disability are often achievable with early and ongoing treatment.
To develop a successful treatment plan, proper diagnosis is required, and ankylosing spondylitis demands a comprehensive exam to use both clinical experience and imaging methods.
We provide every patient with an individual treatment course based on their unique conditions, goals, and symptoms.
The success rate of Spine Mantra in treating back pain and spinal problems is high, with many success stories of patients.
SpineMantra is dedicated to conservative therapy and favours physical therapy and rehabilitation more than surgical interventions.
Our team of experienced physiotherapists and spine specialists works together to provide high-quality, evidence-based care, ensuring effective treatment and better outcomes for patients.